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Arch Pharmacal Res
Q: Sulforaphane
7 , 274ra17 (2015)
SQSTM1/p62 abundance increased at the protein level with all the compounds tested in the study
Comparative work with semaglutide (GLP-1R only) and tirzepatide (GIPR + GLP-1R) provides the field with a comprehensive map of how incremental receptor engagement reshapes downstream pharmacology across pancreatic, hepatic, adipose, and central nervous system tissues
2) The receptor-dependent pathway refers to the direct binding of the LIR motif mitophagy-related receptor to LC3, independent of ubiquitination, and the transport of damaged or redundant mitochondria to autophagosomes to achieve mitochondrial selective autophagic degradation
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