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Biochemical and structural analyses revealed that domain I (residues 1213) forms a dimer with a novel fold and coordinates Zn 2+ through a unique motif 40,41

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Evidence-based lifestyle changesincluding weight loss, increased physical activity, and dietary improvementsremain the cornerstone of NAFLD management

Emerging therapeutic strategies targeting lactate metabolism, including glycolytic inhibition, lactate transporter blockade, combination with immune checkpoint inhibitors, and epigenetic modulation, such as Kla enzyme inhibitors, could potentially aid in subverting the immunosuppressive TME, augmenting immune infiltration, and potentiating chemotherapeutic efficacy (22, 23)

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