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In the landmark 68-week STEP1 obesity trial, participants on 2.4mg recorded a mean body-weight reduction of 14.9%, versus 2.4% on placebo[1]. 50% lost 15% or more of their body weight, and 69% lost at least 10%[1]

Since IGF1R signaling upregulates ZEB1 [94], this suggests another potential point of intersection between the IGF axis and miR-873 actions in CRC

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Higher doses do not increase glucose excretion proportionally and increase the risk of side effects without added benefit