PAUL EDISON: Yeah, so my conclusion for, I would say, for my plenary at the American Academy was that this may very well be like a statin
Beyond 48 hours, potency loss becomes measurable
Experimental inflammatory pathway analysis
Studies have shown that diabetic patients have a significantly higher incidence of herpes zoster (HZ) (9.3 cases per 1000 person-years) and experience greater severity and prolonged chronic pain compared to non-diabetic individuals [14, 16]
Lastly, diabetic patients have a high prorenin levels that could contribute more significantly than renin to the pathogenesis of end-organ damage by stimulating PRR intracellular signaling ( Also at kidney level, RAS compartmentalization and independent regulation have been shown to play an important role in the pathogenesis of hypertension and diabetic nephropathy ( + balance at normal renal perfusion pressures together with promoting glomerular, tubular and interstitial inflammation and fibrosis
The confidence boost is real