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2.2 Wolfram Syndrome Model Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by childhood-onset diabetes mellitus and various neurological manifestations, including progressive optic nerve atrophy, sensorineural hearing loss and cognitive impairment (Kabanovski et al., 2022)

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Some use semaglutide for cardiovascular benefits, metabolic optimization, or appetite management without significant weight reduction

10.1016/j.cell.2021.01.023 16 LiC.LiuB.XuJ.JingB.GuoL.WangL.et al (2023)

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