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Pharmacokinetics (PK): The study of how an organism's system affects a compound, in terms of absorption, distribution, metabolism, and excretion

This drastically reduces sublingual absorption and forces most of the medication through the GI tract, where bioavailability plummets

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Current Zepbound labeling says the majority of nausea, vomiting, and diarrhea events occurred during dose escalation and decreased over time