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Description

In this environment, even a stable drug-polymer matrix can: - Lose miscibility - API might precipitate - Fail to release effectively A ternary APIpolymerwater diagram reveals: - How water impacts solubility - Where miscibility gaps kicks in - How the release mechanism looks like - What the maximum achievable drug load is With this information, formulators can: - Predict release failure before it happens - Understand when the API crashes out - Design ASDs that stay mixed and bioavailable The result

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Compiled from clinical pathology references

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Zunz and La Barre suspected it was due to differences between the qualities of secretin extracts used

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(2017) Molecular and expression analysis of the Allograft inflammatory factor 1 (AIF-1) in the coelomocytes of the common sea urchin Paracentrotus lividus Fish Shellfish Immunol., 71, 136-143 11

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