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For example, high levels of P5P can be converted back to pyridoxal.[ref] The ALPL gene encodes tissue-specific alkaline phosphatase, which plays a role in how P5P (active B6) is transported across membranes, including in the kidneys

Different patient populations, different enrollment criteria, different sites, and different measurement protocols all introduce variability that makes direct numerical comparison imprecise

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Neuroscience 142(4):941952