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While NAPQI is normally detoxified by glutathione, in APAP overdose, glutathione is depleted and NAPQI binds to cysteine on hepatic proteins as 3-(cystein- S -yl) APAP

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As senior study author Maria Daniela Hurtado Andrade, MD, PhD, endocrinologist at Mayo Clinic, explained in a press release: Because this was not a randomized trial, we cannot say hormone therapy caused additional weight loss. According to the study author, its possible the participants using hormone therapy were already engaged in healthier behaviors

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