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The receptor pharmacology is classical: GLP-1R binding on pancreatic beta cells and extra-pancreatic tissues including CNS, stomach, and cardiovascular tissues, with Gs-adenylyl cyclase-PKA downstream signaling

Watkins JD, Carter S, Atkinson G, Koumanov F, Betts JA, Holst JJ, et al

Foods 12:4094

13 Cultural Significance Southeast Asian countries have held a deep-seated fondness for durian since ancient times, a sentiment that has never changed

Activated p53 causes cell death

This might include proof that other treatments have failed or that you have comorbidities like heart disease that make the GLP-1 the best option