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The authors concluded, GLP- 1RA therapy was associated with a significantly lower epilepsy risk compared with DPP-4i use in adults with T2DM [type 2 diabetes]

Patients should report symptoms such as fatigue, cold intolerance, hair loss, or mood changes to their healthcare provider, as these may signal thyroid hormone adjustments are needed

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

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