the sheer volume of information out there, especially regarding novel compounds like 5-Amino-1MQ, can feel overwhelming
Many studies show that people dealing with depression could benefit significantly from vitamin B12 supplements in combination with anti-depressants
An ex vivo study using human skin fibroblasts demonstrates that hydroxocobaslamin penetrates intracellularly to form cyanocabalamin
However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food
[1] [3] Patients with dietary deficiency and intact absorption may require less frequent injections or may be suitable for high-dose oral supplementation instead (typically 50-150 micrograms of cyanocobalamin daily between meals)
With practice, many patients find IM self-injection to be straightforward
