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Abstract Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors

At the same time, Lactobacillus rhamnosus derived extracellular Vesicles can regulate the process of adipocyte metabolism, inhibit the excessive release of inflammatory factors, reduce the chronic inflammatory reaction of adipose tissue, and improve dyslipidemia ( Lactocaseibacillus rhamnosus zz-1 can enhance tight junction protein expression (including ZO-1, occludin, and claudin-1) and promote epithelial barrier repair, thus limiting antigenic load and reducing systemic inflammation ( In addition, probiotics can also occupy the intestinal mucosal surface through competitive exclusion mechanism and reduce the colonization opportunity of pathogens

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This directly demonstrates the protective effect of CAT against ferroptosis in OA chondrocytes

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