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Moreover, based on the reduction in major cardiovascular events observed with use of GLP-1R agonists in cardiovascular outcome trials in people with type 2 diabetes [89], large-scale outcome trials in overweight and obesity have been initiated (ClinicalTrials.gov registration no

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[3] Naver S, Jimenez-Solem E, Christensen M, et al.Dulaglutide: a novel once-weekly glucagon-like peptide-1 receptor agonist[J].Clinical Investigation, 2014, 4(8): 729-743