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This design preserves long-term plasma exposure and steady-state signaling thresholds without requiring continuous infusion protocols
Furthermore, since T-cells are actively recruited into the brain during a pro-inflammatory response, astrocytes modulate the anti-inflammatory response by activating the TNF-related apoptosis-inducing ligand (TRAIL) (Sanmarco et al., 2021)
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This means that high serum B12 levels can persist for some time after large supplemental doses
It has drawn scientific interest for its ability to support neuronal growth and healthy communication between brain cells involved in cognitive performance
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