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Additionally, daily intakes of HC protect the skin against UV melasma, enhances the fibroblast production and extracellular matrix of the skin

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an=16 Cmax- measured peak concerntraion Tmax- observed time of peak concentration t1/2- elimination half-life, calculated by 0.693/Kelim AUC0-24- area under the concentrarion- time curve calculated by the linear trapezoidal rule (Time 0 to 24 hours) CL/F- apparent clearance Distribution Etonogestrel, the active metabolite of desogestrel, was found to be 99% protein bound, primarily to sex hormone-binding globulin (SHBG)

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Molecular docking was used to analyze the binding of P5 and AdipoR1