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[13] [14] For medicines with a narrow therapeutic index, consider appropriate spacing of doses and additional monitoring

For example, specific gene polymorphisms have been linked to variations in depressive symptoms in response to major life stress, underscoring the important role genetic factors play in the disorders pathogenesis [302, 303]

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Dosage Clarity : Clear instructions on duration (e.g., take 2 tablets daily for 8 weeks), not vague phrasing like as needed