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Glutathione can inhibit tyrosinase activity, shift melanin toward a lighter pheomelanin pattern, and neutralize oxidative stress that drives discoloration

Combination therapy in PCOS has demonstrated additive benefits on weight and menstrual cyclicity, highlighting synergistic mechanisms rather than direct reproductive pharmacodynamics

however, the risk is increased when used alongside insulin or sulfonylureas

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Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice