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The timescale of such solvent relaxation depends on the environment, being very fast in non-viscous solvent (happening well within the excited-state lifetime of the fluorophore) but being much slower in motionally restricted environments, such as viscous solvents or the compact, tightly packed interior of a folded protein

Additionally, individuals with a history of heart disease, high blood pressure, or diabetes should be particularly vigilant about any new or unusual chest pain