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Novel SIM1 variants expanding the spectrum of SIM1-related obesity
It belongs to a novel class of drugs known as triple agonists , meaning it simultaneously activates three hormone receptors: GLP-1 (glucagon-like peptide-1) which reduces appetite and slows gastric emptying [9] [10] GIP (glucose-dependent insulinotropic polypeptide) which may enhance insulin secretion and has been suggested in early studies to support fat metabolism Glucagon receptor which may increase energy expenditure and has been proposed to support fat breakdown in the liver, based on early pharmacological data [11] [12] This triple mechanism distinguishes retatrutide from existing approved medicines such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GLP-1/GIP agonist)
Studies show that PRP can improve hair density, hair count, and hair thickness in patients with both androgenic alopecia and telogen effluvium
The injectable vs oral peptides comparison explains why bioavailability matters so much
10.1210/clinem/dgae298 J Clin Endocrinol Metab
H., et al
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