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Unfortunately these increases in HGF are not maintained with disease progression, and the hippocampal HGF/Met system appears to be down regulated in AD patients [95]

Depending on the individual, monthly injections of B12 may be sufficient for some, while others may need more frequent doses

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Consequently, the evidence that it may close and heal the various fistulas and improve anastomosis healing, may be a proof of the fulfilled wound healing concept