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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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and the spatial dimension analyzes the tension between preserving neighborhood fabric and optimizing residential functions

doi: 10.1126/scitranslmed.3006667 26 CrystalASet al

Room temperature storage destroys them within 24 hours