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What This Means for Metabolic Medicine I think the bigger story here isn't about any single drug

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Exercise protects against losing muscle mass Being in a caloric deficit alone can result in 10-30%, even 40% in some cases, of the weight lost from muscle mass

It also implies that any beneficial effects on vascular or RPE pathology may be mediated indirectly, either through neuronal signaling pathways within the retina or via systemic anti-inflammatory and metabolic improvements

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It also resulted in a 13.2% decrease in body weight in an East Asian population with overweight or obesity, with or without T2DM