For example, Nature Made B-Complex with C Caplets include Thiamin (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Pantothenic Acid (Vitamin B5) and Pyridoxine (Vitamin B6) alongside Vitamin C
Photomed Laser Surg 2010, 28 (5), 679684
Although we naturally produce NAD, like most things, it reduces with age and the function of sirtuins become limited
This biochemical tweak allows it to cross the blood-brain barrier , making it not only useful for energy but also for brain health

PubMed NCBI Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain A Systematic Review and Meta-Analysis of Randomized Controlled Trials 2015 Acetyl-L-carnitine in painful peripheral neuropathy- a systematic review 2019 ALC Cognitive Dysfunciton The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction 2008 Current Status of use of Acetyl-L-Carnitine in Neuropsychiatry 2012 Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimers disease 2002 ALC Depression Current Status of use of Acetyl-L-Carnitine in Neuropsychiatry 2012 A Placebo-Controlled Trial of Acetyl-L-Carnitine and -Lipoic Acid in the Treatment of Bipolar Depression 2013 A review of current evidence for acetyl-L-carnitine in the treatment of depression 2014 L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors 2012 ALC High Blood Pressure ALC Migraine Headache ALC Osteoarthritis ALC Statins Emphasis on Education Accurate Clinic promotes patient education as the foundation of its medical care

Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990