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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al

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The 2mg dose balances effectiveness with efficiency

Moreover, some other animal studies have reported a similar effect of riboflavin on SOD ( Reference Liang, Liu and Xu 23 , Reference Hirano, Hamajima and Horiuchi 34 , Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 ) , GPx ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Wang, Mei and Chen 36 ) and catalase ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Lee, Ye and Jones 37 ) activities