Phase 3 clinical trial data shows significant adverse events even in medically supervised participants, including nausea in more than 42 percent of participants and painful nerve sensations (dysesthesia) in more than 12 percent
Pharmacologically, only short-acting GLP-1RAs demonstrate a marked reduction in gastric emptying (156), while chronic activation of GLP-1R results in a waning effect on gastric emptying due to tachyphylaxis
For severe symptomsparticularly signs of significant dehydration, persistent high fever, or bloody diarrhoeaattend your local Emergency Department or call 999 if symptoms are life-threatening
Clarke WL, Cox DJ, Gonder-Frederick LA, Julian D, Schlundt D, Polonsky W (1995) Reduced awareness of hypoglycemia in adults with IDDM
Monitor heart rate at regular intervals consistent with usual clinical practice
'Barbie drug' nasal spray tan plugged by influencers causes cancer, doctors warn A dangerous nasal spray containing 'Barbie drug' melanotan used to tan the skin is being sold openly on websites, online marketplaces, and through social media, in some cases claiming to protect against skin cancer
