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AS-IV notably reduced body weight in aged mice, decreased white adipose tissue, and lowered the liver-to-body weight ratio

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During a three-week treatment period, both Cagrilintide and salmon calcitonin (sCT), another amylin receptor agonist, produced an acute reduction in food intake in WT mice on day 1 by 53% and 42%, respectively, but not in RAMP1/3 KO mice

doi: 10.1210/jc.2010-0482 30 GuX.HanD.ChenW.ZhangL.LinQ.GaoJ.et al