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doi: 10.1002/oby.24222

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In addition, miR-27a/b levels are higher in the sera of patients with type 2 diabetes, while miR-27a/b overexpression suppresses hepatic glucose output and alleviates hyperglycemia by targeting FOXO1

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Mechanistic plausibility does not guarantee a predictable, beneficial outcome in a given patient, and clinicians should frame the combination as biologically interesting rather than clinically proven