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TABLE 1 Summary of cardioprotective and neuroprotective mechanisms by GLP-1R agonists and SGLT2 inhibitors

doi: 10.2337/dc13-2966 49 SattarNGillJMR

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These benefits appear quickly after initiation of treatment with semaglutide in people with overweight or obesity and a history of atherosclerotic heart disease, suggesting that GLP-1 medicines may reduce cardiovascular events in part through weight lossindependent mechanisms (62)