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Long-term safety data remain under investigation and await completion of Phase 3 and post-marketing surveillance

Nat Rev Endocrinol 14:390403

Overall, these findings show that GLP-1R recycling is influenced by persistence of agonist binding within the endosomal compartment, resulting in enhanced insulin-releasing properties of fast-dissociating agonists which maintain an adequate population of cell surface receptors over prolonged periods

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29,46 The spectrum of lasers used ranges from the green lasers (pulsed dye, Q-switched [Qsw], and neodymium [Nd]:yttrium aluminum garnet [YAG] 532) to the far-infrared lasers (CO 2 10,600 nm and erbium [Er]:YAG 2,940 nm) (Figure 7)