NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway
Immediate (first 24 hours): Cold compress for 10 to 15 minutes, repeat 3 to 4 times Do not massage, rub, or apply heat Pressure with a cotton ball for 30 to 60 seconds immediately after withdrawing the needle reduces bleeding Days 2 to 3: Switch to warm compress (10 minutes, 3 to 4 times daily) Warmth promotes reabsorption of trapped blood Arnica cream or gel can be applied (some evidence for faster bruise resolution, though not definitive) Days 4 to 14: Continue warm compresses if desired Allow natural resolution, the bruise will transition through purple, blue, green, and yellow before fading Vitamin K cream may help speed resolution (limited evidence) If you bruise frequently with injections, review your technique
Actin regulation represents TB-500's core function
So we just use an insulin needle and it's just superficial injections on either side of my incision, just as close to my Achilles as possible
We also use Zofran with some of our IV infusion cocktails
It is a huge hurdle we and others in the B12 community are working on to overcome
