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These modifications significantly reduce binding affinity for IGF binding proteins (IGFBPs 1 through 6), extending functional availability in in vitro assay systems

Amato, M

Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry

PMID: 10931172

Later in the illness, some of the dendritic trees impacted by this dis-inhibited glutamatergic input, may plastically retract to blunt the risk of more serious excitotoxicity, and present with overall glutamate reductions in 1 H-MRS

Supplementation may support resilience during hormonal shifts, but always consult a clinician first