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She works in a hospital environment and reports childhood exposure to well water, both potential sources of chronic low-grade heavy metal accumulation

doi: 10.1055/s-0039-1685172 157

Response: We appreciate the applicant's clarification and the commenters' input

Overall, macrophage polarization is more appropriately understood as the result of metabolic network remodeling, in which glucose metabolism, lipid metabolism, and amino acid metabolism do not operate in isolation, but instead form a highly coupled regulatory system at the levels of metabolic flux direction, signal transduction, and epigenetic regulation

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