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Results Discovery of a YPEL5-CTLH-dependent bromodomain (BD)-containing protein 4 (BRD4) degrader To identify MGDs that exploit novel E3 ligases, we used a degron display approach whereby we functionalized a known high-affinity ligand for a target protein with a library of chemical tags containing covalent-acting warheads (Supplementary Table 1)

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Supplementation with subcutaneous vitamin B 12 injections has been shown to improve sleep, gastrointestinal symptoms, hyperactivity, and non-verbal intellectual quotient [45]

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