In addition, it has been suggested that the clinical effects of rimonabant may be associated with antagonism of CB1 receptors not only in the brain, but also in the liver and adipose tissue, leading to reduced lipid storage and increased glucose sensitivity
Cerebrospinal fluid glutamine levels are elevated in HE and correlate with disease severity, supporting a role for ammonia-related metabolism in its pathogenesis [26, 27]
A real-world revenue model would include additional complexities such as tiered insurance reimbursements, geographical pricing variations, the impact of competition over time, potential discounts, patient assistance programs, as well as market and treatment dynamics influencing therapy initiation and discontinuation rates
Scandinavian Journal of Rheumatology
This study further confirmed the neuroprotective potential of -HB in cognition-related neurodegenerative diseases
10.1016/S0031-9384(03)00229-4 [DOI] [PubMed] [Google Scholar] 50.Stephan M, Radicke A, Leutloff S, Schmiedl A, Pabst R, von HS, et al