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When addressing dimeric protein targets, the ability of dimeric therapeutic agents to antagonize paired receptors within a single molecular entity potentially offers superior therapeutic efficacy and target selectivity 15,16

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Specifically, to assess basal analgesia, (i) the first assessment (time "0") was preceded by the application of morphine or saline 30 min before (time "-30 min"), then by the application of the gastric pentadecapeptide BPC 157 or naloxone or saline 20 min before (time "-20 min"), and finally, by the application of the saline 10 min before (time "-10 min")

Instead, these addenda are published and available only on the CMS website

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