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Application Types For the application submission, there are three application types for Class 2 CTGTP
10.1016/j.cell.2012.03.042 37 Dos ReisL
54 Up to date, five main mechanisms are believed to be the dominant causes that are involved in the pathophysiological process of TMAO-induced arrhythmia:1) activated cardiac autonomic nervous system, 35,55 2) inflammation, 28 3) cardiac remodeling and myocardial fibrosis, 56,57 4) oxidative stress, 38,39,58 5) endothelial dysfunction 58 and vascular aging 39 (Table 2)
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Statistical Analyses Mean HbA1c and weight changes from baseline were estimated using an analysis of covariance (ANCOVA) model
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