The economics of pharmaceutical development do create real evidence gaps for unpatentable molecules, and patients pay the cost of that asymmetry
We observed that nucleotide sequence signatures selected from NS5B and E1 regions generally demonstrated stronger discriminant power in differentiating major HCV genotypes and subtypes than that from 5' NCR and CORE regions
Blessing K, Grant JJ, Sanders DS, et al
Hepatic TGFr1 deficiency attenuates lipopolysaccharide/D-galactosamineinduced acute liver failure through inhibiting GSK3Nrf2mediated hepatocyte apoptosis and ferroptosis
New concepts of the pathogenesis of cystic fibrosis lung disease
While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides