adults 70% of whom count as overweight or obese fully 12% are estimated to have used GLP-1s, and many lose 10% or more of their body weight when they do
Studies show that patients who maintain lifestyle changes (reduced calorie intake, regular movement) experience slower weight rebound even after GLP-1 medications leave their system
doi: 10.1095/biolreprod.115.137539 164 SunZLiPWangXLaiSQiuHChenZet al
More recently, a Because tirzepatide is both a Still, its important to keep in mind that there are limitations to these studies, and more long-term research is needed before determining that one medication is more effective than another
Additionally, GLP-1 reduces the release of glucagon, another hormone produced by the pancreas, which typically signals the liver to release stored glucose
Third, the central nervous systems effects on reward processing, stress response, and autonomic balance could produce benefits without altering body composition