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GLP-1 receptor agonists are medications originally developed for type 2 diabetes management but have since gained popularity for weight loss

Tirzepatide is a linear peptide composed of 39 amino acids, which includes a modified part of the GIP sequence at the N-terminus and an amidated sequence borrowed from the GLP-1 agonist exenatide at the C-terminus

These less-bioavailable forms can be taken up and prevent bioavailable or active forms from being used

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However, the researchers did a sensitivity analysis of a 50 mg version and found that it was not as effective as tirzepatide in non-diabetic patients looking to lose weight