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Tirzepatide is the first monomeric peptide with dual activity at both incretin receptors now available for clinical use, and in clinical trials has shown unprecedented effects to reduce blood glucose and body weight

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For this reason, research protocols have excluded subjects with: Uncontrolled hypertension Established cardiovascular disease History of myocardial infarction or stroke The cardiovascular monitoring protocol used in FDA approval trials required blood pressure measurement before and after administration, establishing a safety baseline that researchers in any context should consider

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The protective model based on multiple signature genes would provide a novel strategy to predict the progression of LN