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Hennessy KM, Pollot BE, Clem WC, Phipps MC, Sawyer AA, Culpepper BK, et al

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Downregulation of IL-6, TLR4, PTGS2, and IL-1 expression were also a consequence of BBR treatment [56]

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[8] A standard supplement dose of 2,000 to 5,000 IU D3/day will not approach those thresholds, even accounting for MK-677-mediated enhancement of calcitriol conversion