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The currently available incretin-based therapies are listed in Table 1 , and their physiologic effects are summarized in Figure 1

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This episode provides a clear, evidence-based overview for listeners seeking to understand where these popular health and longevity interventions stand on the spectrum of scientific credibility

The contribution of metabolic mediators to IR Adipokines dysregulation and IR Adipose tissue can secrete various bioactive circulating mediators referred as adipokines, like adiponectin, leptin, chemerin, resistin, visfatin and vaspin, in addition to cytokines and chemokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), IL-1, and monocyte chemoattractant protein-1