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Identification of a mammalian analogue of the reptilian peptide exendin-4

A triple agonist engages three different hormone receptors at once

Semaglutide is a GLP-1 receptor agonist medication that is an active ingredient in medications (Ozempic and Wegovy) that helps regulate blood sugar levels, suppresses appetite, and promotes feelings of fullness

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Progranulin inhibits LPS-induced macrophage M1 polarization via NF-B and MAPK pathways

Finally, it is important to keep in mind that we are still in the early stages of understanding the potential role of GLP-1RAs in addiction treatment and more and larger RCTs are needed