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It is a normal physiological response, and it does not mean the medication has stopped working

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Antioxidants play a significant role in managing melasma by addressing the oxidative stress that contributes to hyperpigmentation

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doi: 10.1016/j.nut.2014.09.013 539 DarziMAbbasiKGhiasvandRAkhavan TabibMRouhaniMH

Lovshin JA, Barnie A, DeAlmeida A, Logan A, Zinman B, Drucker DJ