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In the UK, any medicine must hold a valid Marketing Authorisation granted by the MHRA before it can be legally sold or supplied for medicinal purposes

Neurotoxicol Teratol 1990;12:619-22

Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)

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Short-acting GLP-1 receptor agonists such as exenatide immediate-release (Byetta) and lixisenatide (Adlyxin) must be administered within 60 minutes before meals