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Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

Further, Forstrom et al

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Sitagliptin, a dipeptidyl peptidase-4 inhibitor, ameliorate ERS in both albumin-treated PETCs and the kidneys of diabetic DBA2/J (D2) mice through upregulation of SIRT1 (85)