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36 Those stimuli phosphorylate IB kinase (IKK) complex, 37 and induce degradation of IB, thus releasing NF-B to translocate to nucleus
Initially Too Strange Endocrinologist John Eng played a central role in turning that insight into a drug lead
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Receptor selectivity, tissue exposure, formulation, dose, timing, model choice, and safety signals all sit upstream
Because GLP-1 receptor agonists (typically employed as injectables) increase mealtime insulin secretion and reduce postprandial serum glucose, they may work complementarily with basal insulin treatment to achieve blood sugar goals, especially if basal insulin has not been effective in improving after-meal sugar spikes
