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It can promote tissue repair, reduces inflammation, enhances angiogenesis (new blood vessel formation), and remains stable in gastric juice enabling effective oral administration

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10.1002/jcp.1041190207 97 SakaiK.AokiS.MatsumotoK

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Rheumatologists often adjust allopurinol doses higher than 300mg when needed to reach uric acid goal, although the literature on higher doses of allopurinol is limited