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Weeks 1 to 4: 20 units (0.2 mL) once weekly Weeks 5 to 8: 40 units (0.4 mL) once weekly Weeks 9 to 12: 70 units (0.7 mL) once weekly Weeks 13 to 16: 90 units (0.9 mL) once weekly These are unit measurements based on insulin syringe markings

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Mood changes mild depressive symptoms and low mood occur in 411% of patients taking Roaccutane, while severe depression is rare at less than 1%